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The reduced levels of PPAR, C/EBP, ACC, and FASN in aKO mice were restored to WT levels in HFD-fed aKO;cTg mice (Fig

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The most common side effects are gastrointestinal and tend to improve after the first few weeks: Nausea, vomiting, or diarrhea (most common, especially early on) Constipation or stomach discomfort Reduced appetite Less common but serious side effects include pancreatitis, gallbladder issues, and low blood sugar particularly in patients taking diabetes medications

Reuters , Patients cut GLP-1 doses as coverage tightens (Aug 2025) ( [77] )