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Very rare cases of intestinal obstruction have been reported which can be a serious health problem that requires surgery

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Common effects include: Nausea Constipation Vomiting Diarrhea Bloating Reduced appetite Less common but serious risks may include: Gallbladder disease Pancreatitis Severe dehydration Patients with certain thyroid cancer histories may not be appropriate candidates for some GLP-1 medications

Individual factors and clinical context should guide any decisions

Five 30-minute sessions are more effective for gut motility than two 75-minute sessions because the prokinetic effect of exercise is relatively short-lived, lasting roughly 4-6 hours after the activity

Deviating to more frequent administration does not improve outcomes and may increase adverse event risk in research models