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Here's the TL;DR on vitamin timing: while there is no official medical advice dictating that you should take vitamin supplements at a specific time of day to improve their efficiency, there is quite a lot of research showing that avoiding some vitamin supplements at particular times (or more accurately, with particular meals) can improve absorption, or that taking some vitamins alongside food can reduce the risk of adverse side effects

(2015), based on 15 years of clinical observation, concluded that frequent, high-dose administrations of vitamin B12 injections, in combination with oral folic acid, may respond favorably in alleviating the profound fatigue and cognitive dysfunction seen in ME/CFS patients

Advances in peptide chemistry and analytical technologies enabled detailed investigation of peptide-mediated communication pathways and molecular regulatory mechanisms

However, at the same time that folate deficiency was largely eliminated in these populations, the prevalence of intake exceeding the Tolerable Upper Intake Level of folic acid intake (1 mg/d) increased substantially (6, 22), although this was attributed to the concurrent use of supplements and fortified ready-to-eat cereals rather than to fortification alone