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PMCID: PMC10165082

Administering the injection on the same day each week helps maintain consistent medication levels, which supports both effectiveness and tolerability

Insights into immune dysregulation, cholestatic injury, and bile acid homeostasis have facilitated the development of agents targeting specific pathways, including FXR agonists, PPAR agonists, and immunomodulators

"Without treatment, it is a chronic and relapsing chronic disease that leads to substantial morbidity and mortality," Leddy said at a briefing