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This is generally not a concern for oral or liposomal formats

Site rotation (abdomen, thighs, upper arms) is the commonly reported approach to reduce this reaction

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These patients experience accumulation of plasma acylcarnitines, in part due to a decreased renal clearance of esterified carnitine moieties [54]

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Patients are also encouraged to use sun protection regularly, since UV exposure can impact skin health and potentially reduce the visible benefits of glutathione therapy over time