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While the drug appeared to show higher rates of certain gastrointestinal side effects, such as nausea and diarrhea, especially at the highest dose, they were generally consistent with a previous Phase 3 trial of retatrutide in patients with obesity and a type of knee arthritis pain

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For blood pressure measurements, a 0.8F pressure catheter (SPR-1000, Millar, 8410001) connected to a bioamplifier unit was inserted in the right carotid artery

Both are GLP-1 receptor agonists used for weight management