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13 HFpEF with obesity phenotype is characterized by greater symptom severity, worse functional capacity, more adverse hemodynamics, and greater risk of heart failure hospitalization than those with HFpEF without obesity

Opioid-like peptides derived from food proteins are thought to possess significant biological activity

In addition, high concentrations of leucine and glutamate also activate mTOR signaling and promote myocardial regeneration (70)

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