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Important safety considerations include: Contraindications: Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Pancreatitis risk: Patients should be monitored for persistent severe abdominal pain and tirzepatide discontinued if pancreatitis is suspected Hypoglycemia: Increased risk when combined with insulin or insulin secretagogues

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It has been found in clinical trials that both medications work best when combined with a calorie deficit diet and exercise