Paradoxically, rapidly improving blood sugar can worsen diabetic retinopathy in susceptible individuals, especially those with longstanding, poorly controlled diabetes and high baseline A1c
However, patients with pre-existing stomach conditions, diabetes, or a family history of motility disorders face elevated risk and require careful monitoring before starting therapy
The combination of multiple mechanisms targeting different aspects of tendon repair makes it particularly well-suited for stubborn conditions like elbow tendinopathy
J Clin Endocrinol Metab 107(4):e1339e1347 McGowan BM, Bruun JM, Capehorn M, Pedersen SD, Pietilinen KH, Muniraju HAK, Quiroga M, Varbo A, Lau DCW, STEP 10 Study Group (2024) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial
If you are on a specific dosing schedule and need to delay injections while waiting for a replacement, ask your pharmacy how to handle the gap in treatment
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