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Nitric oxide ultimately leads to the formation of RNS (reactive nitrogen species) which is known to cause mitochondrial damage and is therefore suggested to be a critical agent in chondrocyte function and apoptosis

& Zhao, J

Polyphenols in foods like tea, coffee, berries, and fermented items can reduce nutrient absorption (e.g., iron and zinc)

New England Journal of Medicine , 390(8), 712-724

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In some cases, the dementia and other neurologic symptoms caused by vitamin B 12 deficiency can be reversed by vitamin treatment (42), but reversibility seems to be dependent upon the duration of the associated neurologic complications (41)