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Activation of central TGR5 triggers anti-inflammatory responses: administration of tauroursodeoxycholic acid (TUDCA) in models of acute neuroinflammation induces interleukin-10 (IL-10) expression, suppresses vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) expression, and inhibits microglial migration in a TGR5-dependent manner [171,172]

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