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Furthermore, SCFAs serve as potent anti-inflammatory modulators, capable of inducing Treg differentiation and interleukin secretion in peripheral tissues (182184)

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The mechanisms underlying its weight-reducing effects are not fully understood but may involve enhanced hypothalamic expression of anorexigenic neuropeptides, including proopiomelanocortin POMC, corticotropin-releasing hormone CRH, and thyrotropin-releasing hormone TRH, possibly modulating the POMC/melanocortin-4 receptor (MC4R) pathway [21]

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