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Rats having a full presentation of the azygos vein and portal vein-superior mesenteric vein-inferior mesenteric vein-rectal vein-left iliac vein-inferior vena cava pathway were assessed

One theory is that due to the association between increased abundance of hybrid Insulin/IGF-1 receptors on target human tissues and elevated plasma insulin observed in patients with hyperinsulinemia, that these hybrid IR receptors may cause insulin resistance in certain human tissues

Komatsu M, Kobayashi D, Saito K, Furuya D, Yagihashi A, Araake H, et al