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This then subsequently stimulates downstream IGF-1 production

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The cagrilintide semaglutide mix achieves this through combined mechanisms: both peptides suppress appetite but through different brain pathways (hypothalamic GLP-1 receptors vs brainstem amylin receptors), both slow gastric emptying but through different receptor systems creating additive effects, both improve glucose control through paired mechanisms, and together provide more full body effects

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iScience 27 , 109530 (2024)