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6 Such improvements in natriuresis are linked to reduced sympathetic tone associated with a decrease in leptin signaling, a reduction in renin-angiotensin-aldosterone system activation, and possibly, reduced physical compression of the kidneys due to decreased visceral, retroperitoneal, and renal sinus fat

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In reality, bacteriostatic water for injection is classified as a pharmaceutical product and is generally available only with a prescription at retail pharmacies in the United States

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