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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

The primary endpoint was percent change in body weight

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You cannot fully protect lean mass through protein alone without the stimulus that tells the body to preserve it