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While density for the N-terminal lipidation was not visible in the lower resolution cryo-EM map of the repeat Cagri-CTR-Gs complex ( N = 2), the outward rotamer of H296 ECL2 was observed, congruent with similar interactions between the N-terminal acylation and ECL2

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If youre ever unsure about your technique, if you experience significant pain or discomfort during or after the injection, or if you notice any concerning side effects, contact your healthcare provider immediately