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Leung KC, Johannsson G, Leong GM, Ho KKY

This includes those with conditions like pernicious anemia, certain gastrointestinal disorders, or age-related absorption issues

Cells were exposed for 48 h, the cleared cell extracts were incubated with DEVD-p-nitroanilide and caspase-3 activity was measured spectrophotometrically

Another key player in -KG generation is the mitochondrial enzyme GDH1, which contributes to the accumulation of the subsequent metabolite fumarate

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In some embodiments, the otic formulation or composition comprises about 13% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof