Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
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You L, Kou J, Wang M, et al
At low doses, QUE exhibits antioxidant and anti-inflammatory effects, as demonstrated in a study where a low dose (10 mg/kg) reduced pro-inflammatory markers (TNF- and IL-1) in rats with doxorubicin-induced nephrotoxicity
This leads to a gradual reduction in thyroid function, including decreased output of important thyroid hormones that affect many bodily functions