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Tofidence is authorized to treat moderately to severely active rheumatoid arthritis (RA), polyarticular juvenile idiopathic arthritis and systemic juvenile idiopathic arthritis

This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses

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Here, we showed that Si-based agent alleviate the symptoms of UC model mice through antioxidant and anti-inflammatory effects