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Tocilizumab is beneficial for CRS but may exacerbate immune effector cell-associated neurotoxicity syndrome (ICANS) due to inadequate central nervous system penetration, whereas corticosteroids are favored for ICANS despite apprehensions over their potential to diminish CAR T-cell efficiency

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Managa and Nemadodzi, 2023)

This is the central regulatory problem that full FDA approval would need to solve and it is the reason PCAC reviews for peptides like BPC-157 often hinge on available safety data rather than efficacy evidence from controlled human studies

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