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Several studies have shown that iron is necessary for ferroptosis, and excessive iron deposition has been reported after TBI (Raz et al., 2011)

This was demonstrated by formaldehydes ability to dose-dependently reduce the mitochondrial membrane potential (MMP) of SK-N-SH neuroblastoma cells and inhibit the mitochondrial respiratory enzymes therein, i.e., NADH dehydrogenase (complex I), cytochrome c oxidase (complex IV), and oxidative stress-sensitive aconitase [112, 113]

9 , e1003342 (2013)