drinking coffee on glp 1 The changes I expected after starting a GLP-1? Weight loss. The changes I didn't expect? Those caught me completely off guard. 👀 Some of the foods I used to love don't even TrimRX | Your Morning Brew

When these effects overlap, some people find that drinking alcohol worsens gastrointestinal symptoms

Theodoridis K, Gika H, Kotali A

Severe oxidative stress at the intestinal mucosa may lead to the loss of tight junction proteins through processes including the thiol oxidation, nitration, phosphorylation, and carbonylation of cytoskeletal proteins, tight junction proteins, and intracellular regulatory proteins 89

Serri O, Rasio E, Beauregard H, Hardy J, Somma M

Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects

Overcoming impediments to realize promise