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While it may seem like GLP-1 drugs became a sensation for weight loss out of the blue, the drug class has been around for a while

[Abstract]2022 Sep 6;13(11):3234-3243

Mirtazapine , a noradrenergic and specific serotonergic antidepressant (NaSSA), is known for causing significant weight gain and increased appetite, which may indirectly elevate the risk of metabolic syndrome and fatty liver disease

The half-life of a drug helps us assess the potency and toxicity of a drug over a given amount of time

doi: 10.1099/ijs.0.028670-0, 53 KhuranaK

By days 3 through 7, gastrointestinal effects like constipation or loose stools often emerge as the medication stabilizes in your system