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Instead, CHOP appears to act as a transcriptional decoy

These changes may compromise blood-brain barrier integrity, promote oxidative stress, and initiate a feedback loop that exacerbates neuroinflammation (Bandyopadhyay & Shukla, 2023)

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Moreover, the combined treatment of these two agents proved more effective than single interventions, suggesting potential synergistic effects (Mobasher et al., 2022)

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A TUE would be granted if the criteria outlined in the International Standard for Therapeutic Use Exemptions are met