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Moreover, neuron-specific ablation of GPX4 in the forebrain (cerebral cortex and hippocampus) was associated with an increase in markers associated with ferroptosis including increased lipid peroxidation, extracellular-regulated kinase (ERK) 4 and neuroinflammation (Hambright et al., During ferroptosis, cytosolic ferritin may undergo lysosomal breakdown (ferritinophagy) to further contribute to LIPferritinophagy appears to augment cysteine deficiency-induced ferroptosis (Gao et al., via hyperpolarized mitochondrial membrane potential (Gao et al., 2007

The MTHFR enzyme uses FAD (formed from riboflavin) as a cofactor