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More recent studies employing immunofluorescent stainings, however, failed to show expression in bronchial epithelial cells and fibroblasts, and presence of Gpx3 in the lung was mostly attributed to serum Gpx3 supplied primarily by the kidneys 32,33,48

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In particular, clinical heterogeneity complicates the development of robust clinical endpoints, as small and fragmented patient populations often lack sufficient data to establish reliable outcome measures

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