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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

Pharmacol., 616, 287292 11

2005;11:CR296CR299

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Massive ingestion : Defined as patients with any of the following: Serum acetaminophen level The serum acetaminophen concentration is the basis for diagnosing acute acetaminophen poisoning and determining the need for treatment

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