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The link to autoimmune disease is leaky gut and many patients with MTHFR polymorphisms have imbalanced microbes in the gut which lead to dysbiosis and autoimmune disease -you can read more about that link here My husband and I are both negative for C677T, but both hetero for A1298C

Testicular inflammatory conditions produce pain and may impair local blood flow, which damages germ cells if prolonged

(Air pollution, heavy metals, cigarette smoke, radiation, drugs) Glutathione plays a critical role in defending cells against oxidative stress

Polyamines, such as spermidine, synthesized by Bifidobacterium and Lactobacillus, augment bacterial stress resilience and biofilm development, hence indirectly affecting microbial community stability 49

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