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doi: 10.1016/j.ebiom.2021.103560

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Rauschenberger, L

The 'Two-hit' hypothesis includes inflammatory cytokines, lipid peroxidation, mitochondrial dysfunction and oxidative stress (17), of which oxidative stress is the primary driver (18)

[DOI] [PMC free article] [PubMed] [Google Scholar] 636

Limited body composition data suggest that the majority of weight lost with tirzepatide is from fat mass, with a smaller proportion from lean mass, which is consistent with the pattern seen in other weight-loss interventions