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cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act synergistically to generate downstream signals resulting in increased insulin secretion (8)

References Goodson, Amy, MS, RD, CSSD, LD

Citrus Fruits : Oranges, grapefruits, and lemons contain flavonoids that enhance GLP-1 secretion and improve metabolic health

In clinical scenarios involving older patients with diabetes, heart disease, and kidney disease, providers are often navigating multiple overlapping guidelines

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