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In addition to lowering the levels of blood glucose, as shown in Figure 1 , GLP-1RAs have also been shown to have a positive effect on multiple human tissues

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Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

Prescribed medicines should be taken as usual and not stopped without first discussing it

They may only be prescribed for type 2 diabetes or weight management in patients meeting NICE criteria, with any lymphoedema benefit being indirect through weight loss

Ongoing research is focused on multi-target agonists, oral drugs, and broader therapeutic applications beyond diabetes and obesity, including cardiovascular, kidney, liver, and neurodegenerative conditions