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J Clin Invest 2012;122, 26012612, doi: Zhang, L

There are four main types of multiple sclerosis defined according to the disease course: (i) clinically isolated syndrome, (ii) relapsing-remitting multiple sclerosis, (iii) secondary progressive multiple sclerosis, and (iv) primary progressive multiple sclerosis (for more information, visit the National Multiple Sclerosis Society website) (86)

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The exact amount depends on the patients health, how bad the deficiency is, and the doctors advice