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PubMed Central , doi:10.1161/JAHA.115.002621

Potential Side Effects: Side effects can include redness, swelling, bruising, and in rare cases, allergic reactions

NGF is an important activator of antioxidant pathways mediated by tropomyosin-related kinase receptor A (TrkA)

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In particular, EGFR, a tyrosine kinase receptor of the ErbB family, activates multiple downstream signaling pathways (Oda et al., 2005) such as RAS/MAPK(ERK) and PI3K/AKT/mTOR pathways that collectively promote cell proliferation and survival while inhibit apoptosis