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The authors also report the identification of an over-representation of the HP2 gene encoding zonulin, which increases the risk of increased intestinal permeability

Stay well-hydrated The diuretic effect of spironolactone, combined with the appetite-suppressing, thirst-altering nature of GLP-1s, can easily lead to chronic, low-level dehydration

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Medication Use Certain medications, such as proton pump inhibitors (PPIs) for acid reflux or metformin for diabetes, can interfere with B12 absorption

GLP-1 EFFECT ON LIVER FUNCTION AND GLUCOSE METABOLISM IN HUMAN Disruption of lipid metabolic homeostasis has been recognized as a major cause of NAFLD, which is associated with insulin resistance, T2DM, obesity, and cardiovascular disease

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