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The upregulation of Sirt3 and Sirt5 may have anti-apoptotic activities (Kincaid and Bossy-Wetzel, 2013), but decreased expression of Sirt1 disrupts the Sirt1-PGC-1 inter-relationships (Lavu et al., 2008)

Pharmacokinetics and safety of single and multiple doses of oral n-acetylcysteine in healthy chinese and caucasian volunteers: An open-label, phase i clinical study

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

doi: 10.1016/s0928-4257(00)00148-0

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This downregulation is possibly linked to the regulation of ITPR3 with subsequent reduction of GPX4 and the cystine/glutamate transporter (xCT) and an increment in long-chain ACSL4, thereby enhancing ferroptosis