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Sources: SURMOUNT-5 Clinical Trial (May 2025, The first head-to-head trial comparing the efficacy and safety of tirzepatide versus semaglutide for obesity management, detailing differences in total weight reduction

These medicines mimic the action of naturally occurring GLP-1, a hormone produced in the intestine that plays a crucial role in glucose regulation and appetite control

Retatrutide is a multi-receptor peptide agonist targeting GLP-1, GIP, and glucagon receptors, designed for advanced metabolic research

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This principle is called progressive overload, and it is the core mechanism behind all effective resistance training