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Acerbi, I., Cassereau, L., Dean, I., Shi, Q., Au, A., Park, C., et al

doi: 10.3389/fcvm.2025.1661563 Received 21 July 2025 Accepted 09 October 2025 Published 29 October 2025 Volume 12 - 2025 Edited by Manuel Gmez-Guzmn, University of Granada, Spain Reviewed by Manuel Snchez Santos, University of Granada, Spain Javier Molen Moya, University of Mnster, Germany Updates Copyright 2025 Nzobokela, Muchaili, Mwambungu, Masenga and Kirabo

Minireview: update on incretin biology: focus on glucagon-like peptide-1

Genetic or pharmacological blockade of GIP, GLP-1, or PPAR signaling markedly reduced metabolic effects, supporting a combined incretinPPAR mechanism of action

however, caution is warranted if switching between agents following a reaction

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