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To assess optimal blood handling conditions for reliable measurement of NAD and glutathione metabolites, we investigated their stability in fresh whole blood samples under varying conditions of temperature and time

In addition to oxidative stress, excessive copper ion accumulation alters energy metabolism patterns within cardiomyocytes by inducing abnormal aggregation of thioctylated proteins and loss of iron-sulfur cluster proteins in the respiratory chain complex through direct binding to thioctylated proteins in the mitochondrial TCA cycle (76)

10.1101/gad.1783809 Genes Dev

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& White, P