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SURMOUNT-1 trial (Jastreboff et al., 2022, NEJM ): mean weight loss of 15.0%, 19.5%, and 20.9% respectively over 72 weeks, versus 3.1% on placebo

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In medical weight management, GLP-1based therapies are designed to mimic this hormones activity, helping support metabolic health and sustainable weight loss

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[9] [10] Other radiological investigations may include plain radiographs, ultrasound examination, computed tomography, and positron emission tomography

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Relative contraindications: active gallstone disease, hypertriglyceridemia above 500 mg/dL (which itself causes pancreatitis), or recent heavy alcohol use

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If people with diabetes are missing doses, that could cause concerning effects on blood sugar levels, and the benefits to reduce heart disease risk or kidney disease are likely to be less, Low Wang said

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