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Tryptase, prostaglandins, leukotrienes, and various cytokines continue to cause inflammation, tissue damage, and immune activation even when histamine receptors are blocked

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Some studies have shown accelerated healing in animals and shorter recovery time

[32] Some research suggests that melatonin may enhance certain immune functions while suppressing excessive inflammatory responses, though the clinical significance of these effects in the context of sleep disorders remains an area of ongoing investigation