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Reduced insulin sensitivity as a result of HC and HCHF feeding has also been identified using the hyperinsulinemiceuglycemic clamp technique [17, 45,46,47]

Downstream, HIF-1 upregulates GLUT1 to enhance glucose uptake, induces the expression of glycolytic enzymes, and inhibits pyruvate dehydrogenase (PDH) activity via PDK1preventing pyruvate from entering the TCA cycle

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Beginning in 2014, Dr