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The observation of other anxiety-like behavioral activity in the open field test revealed that the MSG group tended to visit the central zone less often than the control group did, as indicated by the number of crossings ( P 0.05)

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Preparation of nanoparticles P2 (100 mg) or P4 (100 mg) was dissolved in 1 mL DMSO, and the solution were then slowly added dropwise to 10 mL of water

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This prolongs its half-life by up to 15 hours but reduces the affinity to the insulin-like growth factor 1 receptors