Health technology assessment bodies require demonstration of value beyond statistical efficacy, including durability of effect, quality-of-life improvement, and reduction in downstream healthcare costs
======================================== When you search "is Tylenol safe for pregnancy" or "how much Tylenol can I take while pregnant," you encounter alarming headlines linking prenatal acetaminophen use to attention/focus disorders and neurodevelopmental disorders
This one is a staple
Hawk SN, Lanoue L, Keen CL, Kwik-Uribe CL, Rucker RB, Uriu-Adams JY: Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions
- IP Pros: Scrutinize claim scopeMarkush groups, narrow doseschallenge via obviousness
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