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Secondary effects have been documented on mast cells, endothelial cells (blood vessel formation), and the small population of dermal stem cells associated with the hair follicle bulge 1

As an example, during the evaluation of a patient whose primary phenotype was attention-deficit/hyperactivity disorder (ADHD), an incidental finding revealed a pathogenic nonsense mutation in SCN5A , associated with Brugada syndrome

This is particularly relevant for injectable formulations obtained outside standard pharmaceutical channels, where risks of contamination, endotoxin exposure, or improper compounding may exceed any theoretical biologic effect

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