Gastroesophageal reflux disease (GERD): Delayed gastric emptying caused by GLP-1 medications can exacerbate reflux symptoms
In their paper on the study, published in JAMA Ophthalmology , the researchers noted that the substantially increased risk of NAION observed in patients on semaglutide appears not to be due to differences in baseline characteristics between the cohorts. They proposed the possibility that expression of the GLP-1 receptor in the human optic nerve and GLP-1 RA-induced enhanced sympathetic nervous system activity might influence optic nerve head perfusion and potentially increase the risk of NAION. Another notable finding was that the greatest risk of NAION appeared to be within the first year following the prescription of semaglutide, a temporal association that supports a potential drug-induced risk of NAION, the researchers pointed out
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It is entirely possible that the slight rise in optic nerve issues reflects the underlying, advanced vascular damage or high baseline cardiovascular strains already present in patients who require these stronger medications, rather than a direct toxic effect of the drug molecules themselves
That is the novo magic
Im not usually too hungry, but Ill grab a Chomps stick and throw a packet of hydration mix into my big jug of water and head back to my desk
