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UGTs are located in the endoplasmic reticulum of hepatocytes (liver cells) and are also expressed in the gut, kidneys, brain, and skin

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External and iatrogenic causes: Excessive supplementation: High-dose oral supplements or frequent intramuscular injections (hydroxocobalamin or cyanocobalamin) can elevate serum levels, though this rarely causes problems

Muscle carnitine content is rather stable, because the transport of carnitine to and from muscle cells is a very slow process, lasting weeks and even months [59]