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It is not FDA-approved for human therapeutic use

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Earlier evidence for retatrutide comes from a Phase 2 trial in NEJM in 2023, which reported 24.2% weight loss at 12 mg over 48 weeks

Patients with heart, kidney, liver, or endocrine concerns need medical review before using any peptide that affects growth hormone signaling

Modified peptide YY molecule attenuates the activity of NPY/AgRP neurons and reduces food intake in male mice

Guyton explained