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52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

Coskun T, The Lancet (Vol

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Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction

And while regaining weight is likely, its not guaranteed