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MASLD has become increasingly prevalent in the United States, affecting approximately 25% of adults, with rates closely paralleling the obesity epidemic

As Table 1 shows, many agents aiming at different cytokine targets have been developed and applied in practice, such as TNF inhibitors, IL-6 inhibitors, IL-1 inhibitors, IL-15 inhibitors, IL-17 inhibitors, and so on

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Concerns the FDA has raised cluster around unestablished salt forms, impurities or potency variation from low-quality or unlicensed sources, dosing errors from vial-and-syringe self-administration, and unstudied additives such as B12

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